Lee Kerkhof│The Mouse Microbiome and the MinION
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The human/microbiome promises to be a new avenue to treat disease. However, we need model systems and research tools to understand the mechanistic drivers for the mammalian microbiome beyond current correlative metagenomics studies. Rutgers researchers are working with the MinION and mouse models to study how host genetics/exercise behaviour/ and exposure to evironmental toxins influences the host response to aging/obesity/and inflammation through the microbiome. In one set of experiments, diet/exercise can be shown to structure the gut microbiome in male/female mice. We are also investigating a knock-out mouse for adenylyl cyclase as a longevity model to aging and exercise pre-conditioning. In other experiments, ozone expose can lead to blooms of opportunistic pathogens in mouse lungs. Additional studies in two mouse knock-outs in which the inflammatory response to ozone is specifically altered are being used to monitor the mechanisms controlling lung microbiomes.
Flongle, GridION, MinION, MinIT, PromethION, and VolTRAX are currently for research use only.